Monoamine oxidase inhibitors (MAOIs) are a group of medicines that are used in the treatment of depression and anxiety. Since other antidepressants, such as the tricyclics (TCAs) and selective serotonin reuptake inhibitors (SSRIs), have become available, MAOIs have been prescribed much less.

MAOI's have been also used extensively by shamans in mixtures and brews to make entheogens orally active, preventing active components of plants from breaking down inside the stomach.  Ayahuasca, for example, has as it's main ingredient, a MAOI to facilitate the absorption of DMT into the bloodstream.

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